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KEGG (Kyoto Encyclopedia of Genes and Genomes) is a database resource for understanding high-level functions and utilities of the biological system, such as the cell, the organism and the ecosystem, from molecular-level information, especially large-scale molecular datasets generated by genome sequencing and other high-throughput experimental technologies.(Cite by KEGG database)

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Enzymes are large biological molecules responsible for the thousands of metabolic processes that sustain life. They are highly selective catalysts, greatly accelerating both the rate and specificity of metabolic reactions, from the digestion of food to the synthesis of DNA. Most enzymes are proteins, although some catalytic RNA molecules have been identified. Enzymes adopt a specific three-dimensional structure, and may employ organic (e.g. biotin) and inorganic (e.g. magnesium ion) cofactors to assist in catalysis. (Cite by wiki)

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COGs (The Clusters of Orthologous Groups): The protein database of Clusters of Orthologous Groups (COGs) is an attempt to phylogenetically classify the complete complement of proteins (both predicted and characterized) encoded by complete genomes. Each COG is a group of three or more proteins that are inferred to be orthologs, i.e., they are direct evolutionary counterparts. (Cite by NCBI)

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